Total Synthesis of (鈭?-Thallusin: Utilization of Enzymatic Hydrolysis Resolution
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- 作者：Hirofumi Yamamoto ; Yuichi Takagi ; Takaki Oshiro ; Tadashi Mitsuyama ; Ikuo Sasaki ; Naoto Yamasaki ; Akiyo Yamada ; Hiromichi Kenmoku ; Yoshihide Matsuo ; Yusuke Kasai ; Hiroshi Imagawa
- 刊名：Journal of Organic Chemistry
- 出版年：2014
- 出版时间：September 19, 2014
- 年：2014
- 卷：79
- 期：18
- 页码：8850-8855
- 全文大小：320K
- ISSN：1520-6904
文摘
(鈭?-Thallusin, isolated from a marine bacterium, is the only known natural product to act as an algal morphogenesis inducer. Because (鈭?-thallusin can only be obtained in exceedingly limited amounts from microbial cultivation, a synthetic supply of this compound is highly desirable. Here, we describe a novel synthetic pathway to (卤)-thallusin and the first asymmetric synthesis of (鈭?-thallusin utilizing the enzymatic hydrolysis resolution with the combination of lipase PS-30 and lipase M Amamo-10.