Yaku’amides A and B, Cytotoxic Linear Peptides Rich in Dehydroamino Acids from the Marine Sponge Ceratopsion sp.

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• 作者：Reiko Ueoka ; Yuji Ise ; Susumu Ohtsuka ; Shigeru Okada ; Takao Yamori ; Shigeki Matsunaga
• 刊名：Journal of the American Chemical Society
• 出版年：2010
• 出版时间：December 22, 2010
• 年：2010
• 卷：132
• 期：50
• 页码：17692-17694
• 全文大小：160K
• 年卷期：v.132,no.50(December 22, 2010)
• ISSN：1520-5126

文摘

Two cytotoxic peptides, yaku’amides A (1) and B (2), were isolated from the marine sponge Ceratopsion sp. Their planar structures were elucidated on the basis of spectroscopic data, whereas the absolute configurations were determined by a combination of the Marfey’s analysis and dansylation analysis of the total and partial acid hydrolysis products. The growth inhibitory profile of yaku’amide A against a panel of 39 human cancer cell lines was clearly unique and distinguished from other anticancer drugs.