Triterpene Glycosides from Curculigo orchioides and Their Cytotoxic Activity

详细信息    查看全文

• 作者：Akihito Yokosuka ; Koji Sato ; Takao Yamori ; Yoshihiro Mimaki
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：June 25, 2010
• 年：2010
• 卷：73
• 期：6
• 页码：1102-1106
• 全文大小：160K
• 年卷期：v.73,no.6(June 25, 2010)
• ISSN：1520-6025

文摘

Six new cycloartane glycosides (1−6) were isolated from the rhizomes of Curculigo orchioides. The structures of 1−6 were determined by spectroscopic analyses and the results of hydrolytic cleavage. Compounds 1−6, and their common aglycone (1a), were evaluated for cytotoxic activity against HL-60 human leukemia cells. Compounds 1 and 1a showed cytotoxic activity against HL-60 cells with IC₅₀ values of 9.0 and 1.8 μM, respectively. The cancer cell growth inhibition of 1a was also examined using a panel of 39 human cancer cell lines in the Japanese Foundation for Cancer Research.