Camptothecin–Polysaccharide Co-assembly and Its Controlled Release

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• 作者：Yang Yang ; Ying-Ming Zhang ; Dizao Li ; He-Lue Sun ; Hong-Xian Fan ; Yu Liu
• 刊名：Bioconjugate Chemistry
• 出版年：2016
• 出版时间：December 21, 2016
• 年：2016
• 卷：27
• 期：12
• 页码：2834-2838
• 全文大小：379K
• ISSN：1520-4812

文摘

β-Cyclodextrin modified camptothecin (CPT–CD) was synthesized through esterification reaction and “click chemistry” to greatly improve the solubility of CPT in aqueous solution, and then, a supramolecular nanoparticle was constructed by strong noncovalent interaction between β-cyclodextrin and adamantane and amphiphilic interaction by simply mixing CPT–CD and adamantane modified hyaluronic acid (HA–ADA) together. The obtained nanoparticle had a hydrophilic HA shell, which could target and recognize HA receptors overexpressed on the surface of cancer cells, and a hydrophobic CPT core, which could protect CPT from hydrolyzation. The results of cytotoxicity experiments showed that the nanoparticle we have designed in this work exhibited similar anticancer activities to, but with much lower side effects than, the commercial chemotherapeutic drug CPT in vitro. We believe that this work might provide a strategy for improving the treatment performance of CPT in laboratory and clinical settings.