From Propargylamides to Oxazole Derivatives: NIS-Mediated Cyclization and Further Oxidation by Dioxygen

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• 作者：Yancheng Hu ; Ruxia Yi ; Chunxiang Wang ; Xiaoyi Xin ; Fan Wu ; Boshun Wan
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：April 4, 2014
• 年：2014
• 卷：79
• 期：7
• 页码：3052-3059
• 全文大小：338K
• 年卷期：v.79,no.7(April 4, 2014)
• ISSN：1520-6904

文摘

NIS-mediated iodocyclization of N-sulfonyl propargylamides for the synthesis of various oxazolidines and iodoalkylidenedihydrooxazoles via a 5-exo-dig process is developed. The resulting iodoalkylidenedihydrooxazoles can be further transformed into the corresponding oxazoles in the presence of dioxygen.