Carbon Nanotube-Patterned Surface-Based Recognition of Carcinoembryonic Antigens in Tumor Cells for Cancer Diagnosis
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- 作者：Taeyun Kwon ; Jinsung Park ; Gyudo Lee ; Kihwan Nam ; Yong-Min Huh ; Seong-Wook Lee ; Jaemoon Yang ; Chang Young Lee ; Kilho Eom
- 刊名：The Journal of Physical Chemistry Letters
- 出版年：2013
- 出版时间：April 4, 2013
- 年：2013
- 卷：4
- 期：7
- 页码：1126-1130
- 全文大小：350K
- 年卷期：v.4,no.7(April 4, 2013)
- ISSN：1948-7185
文摘
It has been of high significance to devise a biochemical analytical tool kit enabling the detection of few circulating tumor cells (CTCs) for early diagnosis of cancer. Despite recent effort made to detect few CTCs, it is still challenging to sense such cells with their low concentration and/or the minute amount of marker proteins expressed on few CTCs. In this work, we report the label-free recognition of carcinoembryonic antigens (CEAs) expressed on few CTCs by using a carbon nanotube (CNT) sensor coupled with scanning probe microscopy imaging for cancer diagnosis. It is shown that a CNT-patterned surface is able to specifically capture the CEA molecules in the whole cell lysate of CTCs with their concentration even up to 10鈥? cells/mL. Our work sheds light on our bioassay based on a CNT-patterned surface for highly sensitive, label-free detection of marker proteins expressed on few tumor cells, which may open a new avenue in early diagnosis of cancer by providing a novel biochemical analysis tool kit.