Nodulisporiviridins A鈥揌, Bioactive Viridins from Nodulisporium sp.
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- 作者：Qin Zhao ; Guo-Dong Chen ; Xiao-Lin Feng ; Yang Yu ; Rong-Rong He ; Xiao-Xia Li ; Yan Huang ; Wen-Xia Zhou ; Liang-Dong Guo ; Yi-Zhi Zheng ; Xin-Sheng Yao ; Hao Gao
- 刊名：Journal of Natural Products
- 出版年：2015
- 出版时间：June 26, 2015
- 年：2015
- 卷：78
- 期：6
- 页码：1221-1230
- 全文大小：445K
- ISSN：1520-6025
文摘
Eight new viridins, nodulisporiviridins A鈥揌 (1鈥?b>8), were isolated from the extract of an endolichenic fungal strain Nodulisporium sp. (No. 65-17-2-1) that was fermented with potato-dextrose broth. The structures were determined using spectroscopic and X-ray crystallographic analysis. Nodulisporiviridins A鈥揇 (1鈥?b>4) are unique viridins with an opened ring A. The A尾42 aggregation inhibitory activities of 1鈥?b>8 were evaluated using a thioflavin T (ThT) assay with epigallocatechin gallate (EGCG) as the positive control (EGCG IC50 of 0.5 渭M). Nodulisporiviridin G (7) displayed potent inhibitory activity with an IC50 value of 1.2 渭M, and the preliminary trend of activity of these viridins as A尾42 aggregation inhibitors was proposed. The short-term memory assay on an A尾 transgenic drosophila model of Alzheimer鈥檚 disease showed that all eight compounds improved the short-term memory capacity, with potencies close to that of the positive control (memantine).