Kadcoccitones A and B, Two New 6/6/5/5-Fused Tetracyclic Triterpenoids from Kadsura coccinea

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• 作者：Cheng-Qin Liang ; Yi-Ming Shi ; Rong-Hua Luo ; Xing-Yao Li ; Zhong-Hua Gao ; Xiao-Nian Li ; Liu-Meng Yang ; Shan-Zhai Shang ; Yan Li ; Yong-Tang Zheng ; Hong-Bin Zhang ; Wei-Lie Xiao ; Han-Dong Sun
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：December 21, 2012
• 年：2012
• 卷：14
• 期：24
• 页码：6362-6365
• 全文大小：269K
• 年卷期：v.14,no.24(December 21, 2012)
• ISSN：1523-7052

文摘

A pair of new triterpenoid epimers, kadcoccitones A (1) and B (2), together with a new biogenetically related compound kadcoccitone C (3), were isolated from Kadsura coccinea. The epimers featured an unprecedented carbon skeleton with a 6/6/5/5-fused tetracyclic ring system unit and a C₉ side chain. Their structures were determined by spectroscopic data, ECD calculation, and single-crystal X-ray diffraction. Compounds 1 and 3 showed anti-HIV-1 activity with an EC₅₀ value of 47.91 and 32.66 渭g/mL, respectively.