NaGdF4:Yb3+/Er3+@NaGdF4:Nd3+@Sodium-Gluconate: Multifunctional and Biocompatible Ultrasmall Core鈥揝hell Nanohybrids for UCL/MR/CT Multimodal Imagi

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• 作者：Dandan Ma ; Lingjie Meng ; Yuzhong Chen ; Min Hu ; Yanke Chen ; Chen Huang ; Jin Shang ; Ruifeng Wang ; Youmin Guo ; Jian Yang
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：August 5, 2015
• 年：2015
• 卷：7
• 期：30
• 页码：16257-16265
• 全文大小：480K
• ISSN：1944-8252

文摘

Multimodal bioimaging nanoparticles by integrating diverse imaging ingredients into one system, represent a class of emerging advanced materials that provide more comprehensive and accurate clinical diagnostics than conventional contrast agents. Here monodisperse and biocompatible core鈥搒hell nanoparticles, NaGdF₄: Yb³⁺/Er³⁺@NaGdF₄:Nd@sodium-gluconate (termed as GNa-Er@Nd), with about 26 nm in diameter were successfully prepared by a facile two step reactions in high boiling solvents, and followed a ligand exchange process with sodium gluconate. The resulting GNa-Er@Nd nanoparticles were well characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectra (FTIR), and zeta potentials. These nanohybrids present brightly dual-wavelength excited upconversion luminescence (UCL) under both 980 and 793 nm laser because of the synergistic effect of Yb³⁺/Er³⁺ and Nd³⁺. They also exhibited excellent relaxivity parameters (r₁) in magnetic resonance imaging (MRI) and Hounsfield units (HU) in X-ray computed tomography (CT) that are comparable to the clinical contrast agents. Therefore, these small and monodisperse nanoparticles provide options to construct a unique platform for potential multimodal UCL/CT/MRI imaging simultaneously.