Glycosides from the Root of Iodes cirrhosa

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• 作者：Maoluo Gan ; Yanling Zhang ; Sheng Lin ; Mingtao Liu ; Weixia Song ; Jiachen Zi ; Yongchun Yang ; Xiaona Fan ; Jiangong Shi ; Jinfeng Hu ; Jiandong Sun ; Naihong Chen
• 刊名：Journal of Natural Products
• 出版年：2008
• 出版时间：April 2008
• 年：2008
• 卷：71
• 期：4
• 页码：647 - 654
• 全文大小：145K
• 年卷期：v.71,no.4(April 2008)
• ISSN：1520-6025

文摘

Seven new neolignan glycosides (1–7), two arylglycerol glycosides (8, 9), and 18 known glycosides have been isolated from an ethanolic extract of the root of Iodes cirrhosa. Their structures including absolute configurations were determined by spectroscopic and chemical methods. Based on analysis of the NMR data of threo and erythro 8–4′-oxyneolignans and arylglycerols in different solvents, the validity of J_7,8 and Δδ_C8−C7 values to distinguish threo and erythro derivatives was discussed. In the in vitro assays, compound 4 and liriodendrin (17) both showed activity against glutamate-induced PC12 cell damage at 10⁻⁵ M.