Study on the Anthraquinones Separated from the Cultivation of Trichoderma harzianum Strain Th-R16 and Their Biological Activity

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• 作者：Shu-Ying Liu ; Chaur-Tsuen Lo ; Marthandam Asokan Shibu ; Yann-Lii Leu ; Bo-Yuan Jen ; Kou-Cheng Peng
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2009
• 出版时间：August 26, 2009
• 年：2009
• 卷：57
• 期：16
• 页码：7288-7292
• 全文大小：754K
• 年卷期：v.57,no.16(August 26, 2009)
• ISSN：1520-5118

文摘

The biocontrol fungal species of Trichoderma, which colonizes plant roots, are well-known for their potential to control plant pathogens. Six anthraquinones, of which four have been identified for the first time from Trichoderma and two have already been reported in other strains, were purified from Trichoderma harzianum strain Th-R16 to evaluate their biological activities. The structures of the compounds were determined by one- and two-dimensional NMR. The compounds were shown to exhibit stronger antifungal activity than antibacterial activity. Low yield compounds, like 1,5-dihydroxy-3-hydroxymethyl-9,10-anthraquinone, were found to be more active against fungal pathogens than pachybasin and crysophanol, which were found to be the major extracellular metabolites. Test anthraquinones with higher oxidation numbers had better antifungal activity, and their activities were concentration-dependent.