Sulfur Contamination Due to Quenching of Halogenation Reactions with Sodium Thiosulfate: Resolution of Process Problems via Improved Quench Protocols

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• 作者：Yanqiao Xiang ; Pierre-Yves Caron ; Brett M. Lillie ; Rajappa Vaidyanathan
• 刊名：Organic Process Research & Development
• 出版年：2008
• 出版时间：January 2008
• 年：2008
• 卷：12
• 期：1
• 页码：116 - 119
• 全文大小：93K
• 年卷期：v.12,no.1(January 2008)
• ISSN：1520-586X

文摘

Many metal-mediated cross-couplings involve the use of organic halides, which are usually accessed by halogenation reactions. Cross-couplings are sensitive to the presence of impurities in the halides. This paper describes the origin of one such problematic impurity (sulfur) during the synthesis of organic halides and proposes alternatives to minimize or eliminate its formation.