Total Synthesis of Rugulovasine A

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• 作者：Yu-An Zhang ; Qiang liu ; Chao Wang ; Yanxing Jia
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：July 19, 2013
• 年：2013
• 卷：15
• 期：14
• 页码：3662-3665
• 全文大小：256K
• 年卷期：v.15,no.14(July 19, 2013)
• ISSN：1523-7052

文摘

A concise total synthesis of rugulovasine A is achieved by using Uhle鈥檚 ketone derivative as the key intermediate, which was synthesized by intramolecular cyclization via metal鈥揾alogen exchange. Two different routes to construct a spirocyclic butyrolactone subunit involving a Ru-catalyzed cyclocarbonylation and a special Ru-catalyzed double bond rearrangement were studied.