Facile Construction of pH- and Redox-Responsive Micelles from a Biodegradable Poly(β-hydroxyl amine) for Drug Delivery
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- 作者：Dawei Li ; Yazhong Bu ; Lining Zhang ; Xing Wang ; Yanyu Yang ; Yaping Zhuang ; Fei Yang ; Hong Shen ; Decheng Wu
- 刊名：Biomacromolecules
- 出版年：2016
- 出版时间：January 11, 2016
- 年：2016
- 卷：17
- 期：1
- 页码：291-300
- 全文大小：838K
- ISSN：1526-4602
文摘
Here we demonstrate a type of pH and reduction dual-sensitive biodegradable micelles, which were self-assembled by a cationic polymer in an aqueous solution. Due to tumor cells or tissues showing low pH and high reduction concentration, these micelles possessed specific tumor targetability and maximal drug-release controllability inside tumor cells upon changes in physical and chemical environments, but presented good stability at physiological conditions. CCK-8 assay showed that the DOX-loaded micelles had a similar cytotoxicity for MCF-7 tumor cells as free DOX, and blank micelles had a very low cytotoxicity to the cells. Fluorescent microscopy observation revealed that the drug-loaded micelles could be quickly internalized by endosomes to inhibit cancer cell growth. These results indicated these biodegradable micelles, as a novel and effective pH- and redox-responsive nanocarrier, have a potential to improve drug delivery and enhance the antitumor efficacy.