Lipidated Peptidomimetics with Improved Antimicrobial Activity
详细信息 查看全文
- 作者：Yaogang Hu ; Mohamad Nassir Amin ; Shruti Padhee ; Rongsheng E. Wang ; Qiao Qiao ; Ge Bai ; Yaqong Li ; Archana Mathew ; Chuanhai Cao ; Jianfeng Cai
- 刊名：ACS Medicinal Chemistry Letters
- 出版年：2012
- 出版时间：August 9, 2012
- 年：2012
- 卷：3
- 期：8
- 页码：683-686
- 全文大小：241K
- 年卷期：v.3,no.8(August 9, 2012)
- ISSN：1948-5875
文摘
We report a series of lipidated 伪-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated 伪-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus. Their antimicrobial activity and selectivity are comparable or even superior to the clinical candidate pexiganan as well as previously reported linear 伪-AApeptides. The further development of lipidated 伪-AApeptides will lead to a new class of antibiotics to combat drug resistance.