We report a series of
lipidated 伪-AApeptides that mimic the structure and function of natural antimicrobial
lipopeptides. Several short
lipidated 伪-AApeptides show broad-spectrum activity against a range of c
linically related Gram-positive and Gram-negative bacteria as well as fungus. Their antimicrobial activity and selectivity are comparable or even superior to the c
linical candidate pexiganan as well as previously reported
linear 伪-AApeptides. The further development of
lipidated 伪-AApeptides will lead to a new class of antibiotics to combat drug resistance.
Keywords:
antimicrobial peptides; peptidomimetics; drug resistance; lipidation&qsSearchArea=searchText">lipidation; 伪-AApeptides