Visible-Light-Promoted Direct Amination of Phenols via Oxidative Cross-Dehydrogenative Coupling Reaction

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• 作者：Yating Zhao ; Binbin Huang ; Chao Yang ; Wujiong Xia
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：July 15, 2016
• 年：2016
• 卷：18
• 期：14
• 页码：3326-3329
• 全文大小：373K
• 年卷期：0
• ISSN：1523-7052

文摘

A transition-metal-free approach was disclosed for intermolecular aryl C–N bonds formation between phenols and cyclic anilines via cross-dehydrogenative coupling (CDC) amination that was mediated by visible light, wherein K₂S₂O₈ served as an external oxidant. The salient features of this protocol include circumventing the requirement for prefunctionalized starting materials and achieving single regioselectivity of amination adducts at room temperature.