A Cu/Pd Cooperative Catalysis for Enantioselective Allylboration of Alkenes
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- 作者：Tao Jia ; Peng Cao ; Bing Wang ; Yazhou Lou ; Xuemei Yin ; Min Wang ; Jian Liao
- 刊名：Journal of the American Chemical Society
- 出版年：2015
- 出版时间：November 4, 2015
- 年：2015
- 卷：137
- 期：43
- 页码：13760-13763
- 全文大小：372K
- ISSN：1520-5126
文摘
A cooperative Cu/Pd-catalyzed asymmetric three-component reaction of styrenes, B2(pin)2, and allyl carbonates was reported. This reaction, in the presence of chiral CuOAc/SOP and achiral Pd(dppf)Cl2 catalysts, occurs smoothly with high enantioselectivities (up to 97% ee) . The allylboration products, which contain alkene (or diene) unite and alkylboron group, are easily functionalized. The utility of this protocol was demonstrated through the synthesis of an antipsychotic drug, (鈭?-preclamol.