Visualizing Dermal Permeation of Sodium Channel Modulators by Mass Spectrometric Imaging

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• 作者：Livia S. Eberlin ; John V. Mulcahy ; Alexander Tzabazis ; Jialing Zhang ; Huwei Liu ; Matthew M. Logan ; Heather J. Roberts ; Gordon K. Lee ; David C. Yeomans ; Justin Du Bois ; Richard N. Zare
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：April 30, 2014
• 年：2014
• 卷：136
• 期：17
• 页码：6401-6405
• 全文大小：361K
• 年卷期：v.136,no.17(April 30, 2014)
• ISSN：1520-5126

文摘

Determining permeability of a given compound through human skin is a principal challenge owing to the highly complex nature of dermal tissue. We describe the application of an ambient mass spectrometry imaging method for visualizing skin penetration of sodium channel modulators, including novel synthetic analogs of natural neurotoxic alkaloids, topically applied ex vivo to human skin. Our simple and label-free approach enables successful mapping of the transverse and lateral diffusion of small molecules having different physicochemical properties without the need for extensive sample preparation.