Indocyanine-Based Activatable Fluorescence Turn-On Probe for γ-Glutamyltranspeptidase and Its Application to the Mouse Model of Colon Cancer

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• 作者：Seokan Park ; Soo-Yeon Lim ; Sang Mun Bae ; Sang-Yeob Kim ; Seung-Jae Myung ; Hae-Jo Kim
• 刊名：ACS Sensor
• 出版年：2016
• 出版时间：May 27, 2016
• 年：2016
• 卷：1
• 期：5
• 页码：579-583
• 全文大小：464K
• ISSN：2379-3694

文摘

An activatable fluorescent probe from indocyanine was developed for the detection of tumor-enriched γ-glutamyltranspeptidase (γGT). The probe exhibited a dramatic fluorescence enhancement (F/F₀ = 10) as well as a bathochromic shift (>100 nm) upon the treatment of γGT with a low limit of detection of 0.15 unit/L and was further successfully applied as a sensitive probe for γGT in the mouse model of colon cancer.