Mesoporous Multifunctional Upconversion Luminescent and Magnetic 鈥淣anorattle鈥?Materials for Targeted Chemotherapy

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• 作者：Fan Zhang ; Gary B. Braun ; Alessia Pallaoro ; Yichi Zhang ; Yifeng Shi ; Daxiang Cui ; Martin Moskovits ; Dongyuan Zhao ; Galen D. Stucky
• 刊名：Nano Letters
• 出版年：2012
• 出版时间：January 11, 2012
• 年：2012
• 卷：12
• 期：1
• 页码：61-67
• 全文大小：951K
• 年卷期：v.12,no.1(January 11, 2012)
• ISSN：1530-6992

文摘

Nanorattles consisting of hydrophilic, rare-earth-doped NaYF₄ shells each containing a loose magnetic nanoparticle were fabricated through an ion-exchange process. The inner magnetic Fe₃O₄ nanoparticles are coated with a SiO₂ layer to avoid iron leaching in acidic biological environments. This multifunctional mesoporous nanostructure with both upconversion luminescent and magnetic properties has excellent water dispersibility and a high drug-loading capacity. The material emits visible luminescence upon NIR excitation and can be directed by an external magnetic field to a specific target, making it an attractive system for a variety of biological applications. Measurements on cells incubated with the nanorattles show them to have low cytotoxicity and excellent cell imaging properties. In vivo experiments yield highly encouraging tumor shrinkage with the antitumor drug doxorubicin (DOX) and significantly enhanced tumor targeting in the presence of an applied magnetic field.

Keywords:

Nanorattle; ion-exchange; rare earth fluoride; upconversion; magnetic