Divergent Total Synthesis of Taiwaniaquinones A and F and Taiwaniaquinols B and D

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• 作者：Jun Deng ; Ruofan Li ; Yijie Luo ; Jian Li ; Shupeng Zhou ; Yongjian Li ; Jingyu Hu ; Ang Li
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：April 19, 2013
• 年：2013
• 卷：15
• 期：8
• 页码：2022-2025
• 全文大小：297K
• 年卷期：v.15,no.8(April 19, 2013)
• ISSN：1523-7052

文摘

A divergent approach was developed toward the total synthesis of taiwaniaquinoids. An advanced intermediate 5a with trans A/B ring junction was concisely assembled by employing a Bi(OTf)₃-catalyzed cationic cyclization and a Wolff-type ring contraction as key steps. This common intermediate was readily converted to racemic taiwaniaquinones A and F and taiwaniaquinols B and D, respectively.