Sensitivity and Robustness Enhancements by Using a V-Shape Ion Funnel in FTICR-MS

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• 作者：Liulin Deng ; Xiangfeng Chen ; Wan Li ; Ze Wang ; Yiling Elaine Wong ; T.-W. Dominic Chan
• 刊名：Analytical Chemistry
• 出版年：2015
• 出版时间：August 18, 2015
• 年：2015
• 卷：87
• 期：16
• 页码：8073-8077
• 全文大小：324K
• ISSN：1520-6882

文摘

In this paper, a new configuration of the ion funnel interface (i.e., V-shape ion funnel (V-IF)) for high ion transmission efficiency and robustness enhancement was developed and implemented on FTICR-MS. The performance of the V-IF was compared with that of a home-built orthogonal ion funnel. An order of magnitude of improvement in sensitivity was achieved for various peptides and proteins. The performance of the instrument was maintained for a long period by neutral molecule removal. Other ion transmission patterns, such as gentle ion transmission, adduct ion removal, and radio frequency (RF)-driven collision induced dissociation (CID), was also realized in V-IF by varying the RF potentials. V-IF is believed to be a novel ion guide that has promising applications in mass spectrometry.