Rational Design of Multifunctional Gold Nanoparticles via Host鈥揋uest Interaction for Cancer-Targeted Therapy

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• 作者：Wei-Hai Chen ; Qi Lei ; Guo-Feng Luo ; Hui-Zhen Jia ; Sheng Hong ; Yu-Xin Liu ; Yin-Jia Cheng ; Xian-Zheng Zhang
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：August 12, 2015
• 年：2015
• 卷：7
• 期：31
• 页码：17171-17180
• 全文大小：571K
• ISSN：1944-8252

文摘

A versatile gold nanoparticle-based multifunctional nanocomposite AuNP@CD-AD-DOX/RGD was constructed flexibly via host鈥揼uest interaction for targeted cancer chemotherapy. The pH-sensitive anticancer prodrug AD-Hyd-DOX and the cancer-targeted peptide AD-PEG₈-GRGDS were modified on the surface of AuNP@CD simultaneously, which endowed the resultant nanocomposite with the capability to selectively eliminate cancer cells. In vitro studies indicated that the AuNP@CD-AD-DOX/RGD nanocomposite was preferentially uptaken by cancer cells via receptor-mediated endocytosis. Subsequently, anticancer drug DOX was released rapidly upon the intracellular trigger of the acid microenvirenment of endo/lysosomes, inducing apoptosis in cancer cells. As the ideal drug nanocarrier, the multifunctional gold nanoparticles with the active targeting and controllable intracellular release ability hold the great potential in cancer therapy.