Bioactive Anthraquinone Derivatives from the Mangrove-Derived Fungus Stemphylium sp. 33231

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• 作者：Xue-Ming Zhou ; Cai-Juan Zheng ; Guang-Ying Chen ; Xiao-Ping Song ; Chang-Ri Han ; Gao-Nan Li ; Yan-Hui Fu ; Wen-Hao Chen ; Zhi-Gang Niu
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：September 26, 2014
• 年：2014
• 卷：77
• 期：9
• 页码：2021-2028
• 全文大小：411K
• ISSN：1520-6025

文摘

Four new anthraquinone derivatives (1鈥?b>4) and four new alterporriol-type anthranoid dimers (14鈥?b>17), along with 17 analogues, were isolated from the solid rice fermentation of the fungus Stemphylium sp. 33231 obtained from the mangrove Bruguiera sexangula var. rhynchopetala collected from the South China Sea. Their structures were elucidated using comprehensive spectroscopic methods. The absolute configurations of 1, 3, and 4 were determined by single-crystal X-ray diffraction of their derivatives (1a, 3b, and 4a). The absolute configurations of the chiral 17鈥?b>19 were determined by comparing their CD spectra with 21. The inhibitory activities of most of the compounds against seven terrestrial pathogenic bacteria and two cancer cell lines were evaluated.