Discrete Assembly of Synthetic Peptide鈥揇NA Triplex Structures from Polyvalent Melamine鈥揟hymine Bifacial Recognition
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- 作者：Yingying Zeng ; Yaowalak Pratumyot ; Xijun Piao ; Dennis Bong
- 刊名：The Journal of the American Chemical Society
- 出版年：2012
- 出版时间：January 18, 2012
- 年：2012
- 卷：134
- 期：2
- 页码：832-835
- 全文大小：264K
- 年卷期：v.134,no.2(January 18, 2012)
- ISSN：1520-5126
文摘
We have designed a 21-residue 伪-peptide that simultaneously recognizes two decadeoxyoligothymidine (dT10) tracts to form triplexes with a peptide鈥揇NA strand ratio of 1:2. The synthetic peptide side chain displays 10 melamine rings, which provide a bifacial thymine-recognition interface along the length of the 21-residue peptide. Recognition is selective for thymine over other nucleobases and drives the formation of ternary peptide路[dT10]2 complexes as well as heterodimeric peptide路[dT10C10T10] hairpin structures with triplex stems.