Decarboxylative Alkylcarboxylation of 伪,尾-Unsaturated Acids Enabled by Copper-Catalyzed Oxidative Coupling
详细信息 查看全文
- 作者：Bao Gao ; Yinjun Xie ; Zhiqiang Shen ; Lei Yang ; Hanmin Huang
- 刊名：Organic Letters
- 出版年：2015
- 出版时间：October 16, 2015
- 年：2015
- 卷：17
- 期：20
- 页码：4968-4971
- 全文大小：392K
- ISSN：1523-7052
文摘
A facile and general method for copper-catalyzed decarboxylative alkylcarboxylation of cinnamic acids with dimethyl 2,2鈥?azobis(2-methylpropionate) has been developed. The scope and versatility of the reaction was demonstrated, and a broad range of substrates bearing electron-donating and -withdrawing groups on the aromatic rings were all compatible with this reaction to provide desired 尾,纬-unsaturated esters in moderate to good yields. Moreover, 伪,尾-unsaturated acids with a carbonyl group on the 纬-position of acrylic acids also smoothly proceeded to furnish the desired products in good yields.