文摘
The first enantioselective synthesis of (鈭?-conolutinine was achieved in 10 steps. The synthesis featured a catalytic asymmetric bromocyclization of tryptamine to forge the tricycle intermediate. Hydration of an alkene catalyzed by Co(acac)2 was also employed as a key step to diastereoselectively introduce the tertiary alcohol moiety. The absolute configuration of (鈭?-conolutinine was established to be (2S,5aS,8aS,13aR) based on this asymmetric total synthesis.