l-Threonine-Derived Novel Bifunctional Phosphine鈭扴ulfonamide Catalyst-Promoted Enantioselective Aza-Morita鈭払aylis鈭扝illman Reaction
详细信息 查看全文
- 作者：Fangrui Zhong ; Youqing Wang ; Xiaoyu Han ; Kuo-Wei Huang ; Yixin Lu
- 刊名：Organic Letters
- 出版年：2011
- 出版时间：March 18, 2011
- 年：2011
- 卷：13
- 期：6
- 页码：1310-1313
- 全文大小：763K
- 年卷期：v.13,no.6(March 18, 2011)
- ISSN：1523-7052
文摘
A series of novel bifunctional phosphine鈭抯ulfonamide organic catalysts were designed and readily prepared from natural amino acids, and they were utilized to promote enantioselective aza-Morita鈭払aylis鈭扝illman (MBH) reactions. l-Threonine-derived phosphine鈭抯ulfonamide 9b was found to be the most efficient catalyst, affording the desired aza-MBH adducts in high yields and with excellent enantioselectivities.