Highly Enantioselective Synthesis of (S)-α-Alkyl-α,β-diaminopropionic Acids via Asymmetric Phase-Transfer Catalytic Alkylation of 2-Phenyl-2-imidazoline-4-carboxylic Acid tert

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• 作者：Yohan Park ; Sukhoon Kang ; Young Ju Lee ; Taek-Soo Kim ; Byeong-Seon Jeong ; Hyeung-geun Park ; Sang-sup Jew
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：August 20, 2009
• 年：2009
• 卷：11
• 期：16
• 页码：3738-3741
• 全文大小：204K
• 年卷期：v.11,no.16(August 20, 2009)
• ISSN：1523-7052

文摘

An efficient enantioselective synthetic method for (S)-α-alkyl-α,β-diaminopropionic acid is reported. The asymmetric phase-transfer catalytic alkylation of N(1)-Boc-2-phenyl-2-imidazoline-4-carboxylic acid tert -butyl ester in the presence of chiral quaternary ammonium catalyst gave the corresponding alkylated products (93−98% ee) which could be transformed to enantioenriched α-alkyl-α,β-diaminopropionic acids.