Penasins A−E, Long-Chain Cytotoxic Sphingoid Bases, from a Marine Sponge Penares sp

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• 作者：Hideki Ando ; Reiko Ueoka ; Shigeru Okada ; Tsuyoshi Fujita ; Takashi Iwashita ; Takaaki Imai ; Tomoya Yokoyama ; Yuji Matsumoto ; Rob W. M. van Soest ; Shigeki Matsunaga
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：November 29, 2010
• 年：2010
• 卷：73
• 期：11
• 页码：1947-1950
• 全文大小：135K
• 年卷期：v.73,no.11(November 29, 2010)
• ISSN：1520-6025

文摘

Five sphingoid bases, penasin A (1), penasin B (2), and a mixture of penasins C−E (3−5), were identified from a marine sponge Penares sp. as cytotoxic constituents. The structure of the common polar head part was assigned by analysis of the NMR data, whereas the structures of the long aliphatic chains including the locations of double bond(s) and a branched methyl group were determined by analysis of tandem FABMS and ¹³C NMR data together with the GC-MS analysis of ozonolysis products. The absolute configuration of the headgroup was defined for the mixture of 3−5 by the modified Mosher method. Penasins exhibit moderate cytotoxicity against HeLa and P388 cells.