Synthesis of Water-Tolerant Indium Homoenolate in Aqueous Media and Its Application in the Synthesis of 1,4-Dicarbonyl Compounds via Palladium-Catalyzed Coupling with Acid Chloride

详细信息    查看全文

• 作者：Zhi-Liang Shen ; Kelvin Kau Kiat Goh ; Hao-Lun Cheong ; Colin Hong An Wong ; Yin-Chang Lai ; Yong-Sheng Yang ; Teck-Peng Loh
• 刊名：Journal of the American Chemical Society
• 出版年：2010
• 出版时间：November 17, 2010
• 年：2010
• 卷：132
• 期：45
• 页码：15852-15855
• 全文大小：182K
• 年卷期：v.132,no.45(November 17, 2010)
• ISSN：1520-5126

文摘

The first water-tolerant, ketone-type indium homoenolate was synthesized via the oxidative addition of In/InCl₃ to enones. The reaction proceeds exclusively in aqueous media. Both indium and indium(III) chloride are necessary for the smooth conversion of the reaction. Similar results were obtained when InCl or InCl₂ was used in place of In/InCl₃. The synthetic utility of the indium homoenolate was demonstrated through the synthesis of 1,4-dicarbonyl compounds via palladium-catalyzed coupling of indium homoenolate with acid chloride.