Resveratrol Oligomers Inhibit Biofilm Formation of Escherichia coli O157:H7 and Pseudomonas aeruginosa

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• 作者：Jin-Hyung Lee ; Yong-Guy Kim ; Shi Yong Ryu ; Moo Hwan Cho ; Jintae Lee
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：January 24, 2014
• 年：2014
• 卷：77
• 期：1
• 页码：168-172
• 全文大小：451K
• ISSN：1520-6025

文摘

Biofilm formation is closely related to bacterial infection and is also a mechanism of antimicrobial resistance. Hence, the antibiofilm approach provides an alternative to an antibiotic strategy. In this study, the antibiofilm activities of resveratrol (1) and five of its oligomers, namely, 蔚-viniferin (2), suffruticosol A (3), suffruticosol B (4), vitisin A (5), and vitisin B (6), were investigated against enterohemorrhagic Escherichia coli O157:H7 and Pseudomonas aeruginosa PA14. Vitisin B (6), a stilbenoid tetramer, was found to inhibit biofilm formation by the two bacteria the most effectively and at 5 渭g/mL inhibited E. coli O157:H7 biofilm formation by more than 90%.