Bioconjugation of Luminescent Silicon Quantum Dots for Selective Uptake by Cancer Cells

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• 作者：Folarin Erogbogbo ; Chen-An ; Tien ; Ching-Wen Chang ; Ken-Tye Yong ; Wing-Cheung Law ; Hong Ding ; Indrajit Roy ; Mark T. Swihart ; Paras N. Prasad
• 刊名：Bioconjugate Chemistry
• 出版年：2011
• 出版时间：June 15, 2011
• 年：2011
• 卷：22
• 期：6
• 页码：1081-1088
• 全文大小：1035K
• 年卷期：v.22,no.6(June 15, 2011)
• ISSN：1520-4812

文摘

Conventional quantum dots have great potential in cancer-related imaging and diagnostic applications; however, these applications are limited by concerns about the inherent toxicity of their core materials (e.g., cadmium, lead). Virtually all imaging applications require conjugation of the imaging agent to a biologically active molecule to achieve selective uptake or binding. Here, we report a study of biocompatible silicon quantum dots covalently attached to biomolecules including lysine, folate, antimesothelin, and transferrin. The particles possess desirable physical properties, surface chemistry, and optical properties. Folate- and antimesothelin-conjugated silicon quantum dots show selective uptake into Panc-1 cells. This study contributes to the preclinical evaluation of silicon quantum dots and further demonstrates their potential as an imaging agent for cancer applications.