Organocatalytic Activation of Alkylacetic Esters as Enolate Precursors to React with 伪,尾-Unsaturated Imines

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• 作者：Lin Hao ; Shaojin Chen ; Jianfeng Xu ; Bhoopendra Tiwari ; Zhenqian Fu ; Tong Li ; Jieyan Lim ; Yonggui Robin Chi
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：October 4, 2013
• 年：2013
• 卷：15
• 期：19
• 页码：4956-4959
• 全文大小：269K
• 年卷期：v.15,no.19(October 4, 2013)
• ISSN：1523-7052

文摘

Asymmetric functionalization of alkylacetic esters and their derivatives is traditionally achieved via preformed enolates with chiral auxiliaries. Catalytic versions of such transformations are attractive but challenging. A direct catalytic activation of simple alkylacetic esters via N-heterocyclic carbene organocatalysts to generate chiral enolate intermediates for highly enantioselective reactions is reported.