Heteronuclear Gd-99mTc Complex of DTPA-Bis(histidylamide) Conjugate as a Bimodal MR/SPECT Imaging Probe
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- 作者：Ji-Ae Park ; Jung Young Kim ; Hee-Kyung Kim ; Wonho Lee ; Sang Moo Lim ; Yongmin Chang ; Tae-Jeong Kim ; Kyeong Min Kim
- 刊名：ACS Medicinal Chemistry Letters
- 出版年：2012
- 出版时间：April 12, 2012
- 年：2012
- 卷：3
- 期：4
- 页码：299-302
- 全文大小：250K
- 年卷期：v.3,no.4(April 12, 2012)
- ISSN：1948-5875
文摘
The work describes the synthesis and in vivo application of heterotrimetallic complexes of the type {Gd(H2O)[(M(H2O)(CO)3)2(1)]} {1 = DTPA-bis(histidyl-amide); M = Re (3a); 99mTc (3b)} for dual modality MR/SPECT imaging. Here, the DTPA-bis(histidylamide) conjugate functions as a trinucleating chelate incorporating Gd in the DTPA core with Re or 99mTc in the pair of histidylamide side arms. The two complexes are chemically equivalent as revealed by HPLC, and their 鈥渃ocktail mixture鈥?(3a + 3b) has demonstrated itself to be essentially a single bimodal imaging probe. The present system has thus overcome the sensitivity difference problem between MRI and SPECT and paved the way for practical applications.