Chloropestolide A, an Antitumor Metabolite with an Unprecedented Spiroketal Skeleton from Pestalotiopsis fici

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• 作者：Ling Liu ; Yan Li ; Shuchun Liu ; Zhihui Zheng ; Xulin Chen ; Hua Zhang ; Liangdong Guo ; Yongsheng Che
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：July 2, 2009
• 年：2009
• 卷：11
• 期：13
• 页码：2836-2839
• 全文大小：199K
• 年卷期：v.11,no.13(July 2, 2009)
• ISSN：1523-7052

文摘

Chloropestolide A (1), a highly functionalized spiroketal with an unprecedented skeleton derived from a chlorinated bicyclo-[2.2.2]-oct-2-en-5-one ring and a 2,6-dihydroxy-4-methylbenzoic acid unit, has been isolated from the scale-up fermentation extract of Pestalotiopsis fici. The structure of 1 was elucidated by NMR spectroscopy and X-ray crystallography. 1 could be derived from the same Diels−Alder precursors as 2 and showed significant inhibitory effects on growth of two human cancer cell lines, HeLa and HT29, with GI₅₀ values of 0.7 and 4.2 μM, respectively.