Enantioselective Synthesis of 4-Substituted 4,5-Dihydro-1H-[1,5]benzodiazepin-2(3H)-ones by the Lewis Base-Catalyzed Hydrosilylation

详细信息    查看全文

• 作者：Xing Chen ; Yongsheng Zheng ; Chang Shu ; Weicheng Yuan ; Bo Liu ; Xiaomei Zhang
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：November 4, 2011
• 年：2011
• 卷：76
• 期：21
• 页码：9109-9115
• 全文大小：298K
• 年卷期：v.76,no.21(November 4, 2011)
• ISSN：1520-6904

文摘

Enantioselective synthesis of 4-substituted 4,5-dihydro-1H-[1,5]benzodiazepin-2(3H)-ones has been accomplished through chiral Lewis base-catalyzed hydrosilylation. The corresponding products were obtained in excellent yields (up to 99%) and enantioselectivities (up to 98%). The absolute configuration of product 3n has been determined as S by X-ray crystallographic analysis.