Synthesis of Symmetrical and Unsymmetrical N,N鈥?Diaryl Guanidines via Copper/N-Methylglycine-Catalyzed Arylation of Guanidine Nitrate

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• 作者：Hui Xing ; Ye Zhang ; Yisheng Lai ; Yongwen Jiang ; Dawei Ma
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：June 15, 2012
• 年：2012
• 卷：77
• 期：12
• 页码：5449-5453
• 全文大小：245K
• 年卷期：v.77,no.12(June 15, 2012)
• ISSN：1520-6904

文摘

CuI/N-methylglycine-catalyzed coupling reaction of guanidine nitrate with both aryl iodides and bromides takes place at 70鈥?00 掳C, affording symmetrical N,N鈥?diaryl guanidines with good to excellent yields. Unsymmetrical N,N鈥?diaryl guanidines can be assembled via monoarylation of guanidine nitrate with aryl iodides bearing a strong electron-withdrawing group and subsequent coupling with another aryl iodide.