Assembly of N,N-Disubstituted Hydrazines and 1-Aryl-1H-indazoles via Copper-Catalyzed Coupling Reactions

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• 作者：Xiaodong Xiong ; Yongwen Jiang ; Dawei Ma
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：May 18, 2012
• 年：2012
• 卷：14
• 期：10
• 页码：2552-2555
• 全文大小：286K
• 年卷期：v.14,no.10(May 18, 2012)
• ISSN：1523-7052

文摘

CuI-catalyzed coupling of N-acyl-N鈥?substituted hydrazines with aryl iodides takes place at 60鈥?0 掳C to afford N-acyl-N鈥?N鈥?disubstituted hydrazines regioselectively and thereby gives a facile method for assembling N,N-diaryl hydrazines. N-Acyl-N鈥?substituted hydrazines can also react with 2-bromoarylcarbonylic compounds at 60鈥?25 掳C under the catalysis of CuI/4-hydroxy-l-proline to provide 1-aryl-1H-indazoles.