Assembly of Substituted 3-Aminoindazoles from 2-Bromobenzonitrile via a CuBr-Catalyzed Coupling/Condensation Cascade Process

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• 作者：Lanting Xu ; Yinsheng Peng ; Qiangbiao Pan ; Yongwen Jiang ; Dawei Ma
• 刊名：The Journal of Organic Chemistry
• 出版年：2013
• 出版时间：April 5, 2013
• 年：2013
• 卷：78
• 期：7
• 页码：3400-3404
• 全文大小：299K
• 年卷期：v.78,no.7(April 5, 2013)
• ISSN：1520-6904

文摘

CuBr-catalyzed coupling reaction of 2-halobenzonitriles with hydrazine carboxylic esters and CuBr/4-hydroxy-l-proline-catalyzed coupling reaction of 2-bromobenzonitriles with N鈥?arylbenzohydrazides proceed smoothly at 60鈥?0 掳C to provide substituted 3-aminoindazoles through a cascade coupling/condensation (or coupling/deacylation/condensation) process. A wide range of 3-aminoindazoles with substituents at both the 1-position and the phenyl ring part can be prepared from the corresponding coupling partners.