Assembly of Primary (Hetero)Arylamines via CuI/Oxalic Diamide-Catalyzed Coupling of Aryl Chlorides and Ammonia

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• 作者：Mengyang Fan ; Wei Zhou ; Yongwen Jiang ; Dawei Ma
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：December 4, 2015
• 年：2015
• 卷：17
• 期：23
• 页码：5934-5937
• 全文大小：387K
• ISSN：1523-7052

文摘

A general and practical catalytic system for aryl amination of aryl chlorides with aqueous or gaseous ammonia has been developed, with CuI as the catalyst and bisaryl oxalic diamides as the ligands. The reaction proceeds at 105鈥?20 掳C to provide a diverse set of primary (hetero)aryl amines in high yields with various functional groups.