Cytotoxic and Antibacterial Marfuraquinocins from the Deep South China Sea-Derived Streptomyces niveus SCSIO 3406

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• 作者：Yongxiang Song ; Hongbo Huang ; Yuchan Chen ; Jie Ding ; Yun Zhang ; Aijun Sun ; Weimin Zhang ; Jianhua Ju
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：December 27, 2013
• 年：2013
• 卷：76
• 期：12
• 页码：2263-2268
• 全文大小：310K
• ISSN：1520-6025

文摘

Four new sesquiterpenoid naphthoquinones, marfuraquinocins A鈥揇 (1鈥?b>4), and two new geranylated phenazines, phenaziterpenes A (5) and B (6), were isolated from the fermentation broth of Streptomyces niveus SCSIO 3406, which originated from a South China Sea sediment sample obtained from a depth of 3536 m. The structures of 1鈥?b>6 were elucidated on the basis of extensive MS and one-dimensional and two-dimensional NMR spectroscopic analyses. In a panel of cytotoxicity and antibacterial assays, 1 and 3 were found to inhibit a NCI-H460 cancer cell line with IC₅₀ values of 3.7 and 4.4 渭M, respectively. Compounds 1, 3, and 4 exhibited antibacterial activities against Staphylococcus aureus ATCC 29213 with equivalent MIC values of 8.0 渭g/mL; compounds 3 and 4 each showed antibacterial activity against methicillin-resistant Staphylococcus epidermidis (MRSE) shhs-E1 with MIC values of 8.0 渭g/mL.