Halogenated Anthraquinones from the Marine-Derived Fungus Aspergillus sp. SCSIO F063

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• 作者：Hongbo Huang ; Fazuo Wang ; Minghe Luo ; Yuchan Chen ; Yongxiang Song ; Weimin Zhang ; Si Zhang ; Jianhua Ju
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：July 27, 2012
• 年：2012
• 卷：75
• 期：7
• 页码：1346-1352
• 全文大小：302K
• 年卷期：v.75,no.7(July 27, 2012)
• ISSN：1520-6025

文摘

Metabolomic investigations focusing on the marine-derived fungus Aspergillus sp. SCSIO F063 have unveiled seven new chlorinated anthraquinones (1鈥?b>7) related to averantin, together with five known analogues (11鈥?b>15) when the fungus was fermented using sea salt-containing potato dextrose broth. Through the addition of sodium bromide to the broth, two new brominated anthraquinones (8, 9) and one new nonhalogenated anthraquinone (10) were obtained from the fungal mycelia. Their structures were elucidated by extensive spectroscopic analyses including MS and 1D and 2D NMR data. One metabolite, 6-O-methyl-7-chloroaveratin (2), displayed inhibition activity against three human tumor cell lines, SF-268, MCF-7, and NCI-H460, with IC₅₀ values of 7.11, 6.64, and 7.42 渭M, respectively.