Panax ginseng Extract Rich in Ginsenoside Protopanaxatriol Attenuates Blood Pressure Elevation in Spontaneously Hypertensive Rats by Affecting the Akt-Dependent Phosphorylation of Endothelial Nitric O
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- 作者：So Young Hong ; Ji Yeon Kim ; Hee Yoon Ahn ; Jae-Ho Shin ; Oran Kwon
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2012
- 出版时间：March 28, 2012
- 年：2012
- 卷：60
- 期：12
- 页码：3086-3091
- 全文大小：246K
- 年卷期：v.60,no.12(March 28, 2012)
- ISSN：1520-5118
文摘
Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a fundamental regulator of systemic blood pressure. Ginsenosides from Panax ginseng have been investigated in vitro for the molecular and biochemical mechanisms by which they stimulate NO release in vascular endothelial cells; however, little research has been done to confirm the physiological relevance of these in vitro studies. To address this research gap, the effects of a P. ginseng extract rich in ginsenosides from protopanaxatriol on spontaneously hypertensive rats (SHRs) was examined. Ginseng extract administration stimulated nongenomic Akt-mediated eNOS activation, enhanced NO production, improved vessel wall thickening, and alleviated hypertension in SHRs, confirming the physiological relevance of previous in vitro studies with ginsenosides.