Concise Synthesis of v-Coelenterazines

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• 作者：Takamitsu Hosoya ; Rie Iimori ; Suguru Yoshida ; Yuto Sumida ; Yuiko Sahara-Miura ; Jun-ichi Sato ; Satoshi Inouye
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：August 7, 2015
• 年：2015
• 卷：17
• 期：15
• 页码：3888-3891
• 全文大小：386K
• ISSN：1523-7052

文摘

A novel synthetic method for v-coelenterazine (v-CTZ), which is a vinylene-bridged analog of native CTZ with a large red-shifted luminescence property, is described. The synthesis was achieved in a concise way through the use of three sequential cross-coupling reactions and ring-closing metathesis (RCM). A newly synthesized C2-modified trifluoromethyl analog cf3-v-CTZ showed slightly more red-shifted luminescence than v-CTZ when it was used as a substrate for Renilla luciferases.