Functional Platform for Controlled Subcellular Distribution of Carbon Nanotubes

详细信息    查看全文

• 作者：Maged F. Serag ; Noritada Kaji ; Enrica Venturelli ; Yukihiro Okamoto ; Kazuyoshi Terasaka ; Manabu Tokeshi ; Hajime Mizukami ; Kevin Braeckmans ; Alberto Bianco ; Yoshinobu Baba
• 刊名：ACS Nano
• 出版年：2011
• 出版时间：November 22, 2011
• 年：2011
• 卷：5
• 期：11
• 页码：9264-9270
• 全文大小：975K
• 年卷期：0
• ISSN：1936-086X

文摘

As nanoparticles can cross different cellular barriers and access different tissues, control of their uptake and cellular fate presents a functional approach that will be broadly applicable to nanoscale technologies in cell biology. Here we show that the trafficking of single-walled carbon nanotubes (SWCNTs) through various subcellular membranes of the plant cell is facilitated or inhibited by attaching a suitable functional tag and controlling medium components. This enables a unique control over the uptake and the subcellular distribution of SWCNTs and provides a key strategy to promote their cellular elimination to minimize toxicity. Our results also demonstrate that SWCNTs are involved in a carrier-mediated transport (CMT) inside cells; this is a phenomenon that scientists could use to obtain novel molecular insights into CMT, with the potential translation to advances in subcellular nanobiology.