Double Helical Oligoresorcinols Specifically Recognize Oligosaccharides via Heteroduplex Formation through Noncovalent Interactions in Water

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• 作者：Hidetoshi Goto ; Yoshio Furusho ; Eiji Yashima
• 刊名：Journal of the American Chemical Society
• 出版年：2007
• 出版时间：July 25, 2007
• 年：2007
• 卷：129
• 期：29
• 页码：9168 - 9174
• 全文大小：581K
• 年卷期：v.129,no.29(July 25, 2007)
• ISSN：1520-5126

文摘

We report on the oligosaccharide recognition through noncovalent interactions in water basedon a unique supramolecular homoduplex-to-heteroduplex transformation of the oligoresorcinol nonameras a fully artificial receptor. The oligoresorcinol forms a double helix in water, which unravels and entwinesupon complexation with specific oligosaccharides with a particular chain length and glucosidic linkage pattern,thus generating the heteroduplex with an excess one-handed helical conformation that can be readilymonitored and further quantified by absorption, circular dichroism, and NMR spectroscopies.