文摘
Novel C-8a functionalized tricyclic compounds having cyanoenones in rings A and C have been synthesized and biologicallyevaluated. Among them, compounds with acetylene groups at C-8ashow extremely high potency in in vitro and in vivo bioassays for anti-inflammatory and cytoprotective activities. Both in vitro and in vivopotencies are markedly higher than those of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), which is being evaluated as ananticancer drug in phase I clinical trials.