Organocatalyzed Enantioselective Michael Addition of 2-Hydroxy-1,4-naphthoquinone to 尾,纬-Unsaturated 伪-Ketophosphonates胃
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- 作者：Tao Liu ; Youming Wang ; Guiping Wu ; Haibin Song ; Zhenghong Zhou ; Chuchi Tang
- 刊名：Journal of Organic Chemistry
- 出版年：2011
- 出版时间：May 20, 2011
- 年：2011
- 卷：76
- 期：10
- 页码：4119-4124
- 全文大小：807K
- 年卷期：v.76,no.10(May 20, 2011)
- ISSN：1520-6904
文摘
By employing a cinchonine-based thiourea as catalyst, highly enantioselective Michael addition reactions of 2-hydroxy-1,4-naphthoquinone to 尾,纬-unsaturated 伪-ketophosphonates were realized. The reaction afforded the corresponding 尾-substituted carboxylates in excellent yields with high levels of enantioselectivities (94鈭?gt;99% ee) upon quenching the generated parent structures with DBU and MeOH as a second nucleophile.